Pre-Seed · Round open

The cognitive digital twin for home care in Alzheimer’s and dementia

We tell reversible acute deterioration apart from neurodegenerative progression by comparing each patient against their own personal baseline — not a population threshold.

Pre-Seed Round · €500k Clinical partnership with an Italian IRCCS

Deepleey S.r.l. — Italy, 2026

Duomea — Home monitoring for Alzheimer's and dementia care

The clinical context

A signal that is read too late today

Patients with Alzheimer’s and senile dementia who are still semi-independent stay at home, where there is no continuous clinical observation between visits.

1

Two trajectories, one apparent symptom

An acute cognitive decline can have a reversible cause (infection, medication, dehydration, delirium) or be the onset of neurodegenerative progression. From the outside, at first, they look the same.

2

Continuous home monitoring doesn’t exist

Between one visit and the next there is no structured clinical observation: families and caregivers are left alone to read the signals.

3

Delay has a clinical and human cost

A late differential diagnosis means either a reversible therapy missed, or an unnecessary alarm for a transient episode — either way, a growing burden on the caregiver.

Cognitive Twin

A model of the individual patient, not a population threshold

The proprietary core is a computational model of the individual, updated daily through structured voice interaction, ambient computer vision and behavioral data.

Personal, non-stationary baseline

The disease progresses: the patient’s baseline evolves over time. Deviation detection is built to model this non-stationarity, not to assume a fixed reference.

The temporal signature of deviation

We tell reversible acute deterioration apart from neurodegenerative progression by looking at how the signal changes: sudden onset vs. gradual drift, fluctuating vs. monotonic, single- vs multi-domain.

Minimal, agent-agnostic hardware

An off-the-shelf tablet and two ambient cameras, about €800 per installation. The architecture exposes a standard interface: any compatible device becomes a Duomea agent.

Built as a platform

The infrastructure — multimodal ingestion, personal baseline, deviation detection, clinical reporting — is designed to be condition-agnostic, not tied to a single use case.

Class I → IIaMDR regulatory pathway, disciplined against Rule 11
ISO 13485QMS set up from day one, not retrofitted
∼€800Off-the-shelf hardware cost per installation
Italy-firstAnchored to an IRCCS partnership and the national health reform

Clinical validation

Partnership with an Italian IRCCS

The clinical study that generates the proprietary longitudinal dataset and validates the deviation-detection model.

What’s already underway

  • LOI signed with the IRCCS; term sheet under negotiation on data and derived-model ownership.
  • Sponsor-funded study, milestone-based payments only — no fee, no revenue for Duomea.
  • Informed consent covering secondary commercial use from the first patient (GDPR Art. 9).

Why it matters to an investor

  • A proprietary clinical dataset, neither synthetic nor purchased — built for the specific regulatory claim.
  • A two-stage pathway (Class I → IIa) disciplined by claim language, not by the product.
  • An Italy-first sequence anchored to a real clinical partner, not an abstract expansion plan.

The team

Who executes

GT

Gabriele Torre

Founder & Chief AI

Models, ML pipelines, Cognitive Twin architecture.

FM

Fabrizio Malfanti

Chief Technical Officer

Digital twin architecture, product and technical direction.

AD

Alice De Luca, PhD

Clinical & Regulatory

MDR, CER/CEP/PMCF — previously IIT, Movendo.

GR

Giuseppe Russo

Senior Data Scientist

Clinical and behavioral data modeling.

MP

Michela Paparella

Co-founder & Chief Strategy and Ecosystem Officer

Stakeholder ecosystem, patient/caregiver engagement, institutional partnerships, adoption.

CE

Cristiano Ercolani

Commercial & Capital

Enterprise IT, prior VC fundraising and M&A exits.

CEO

CEO

In recruiting

Track record in clinical evidence → reimbursement. Equity 8–12%, board seat.

Gabriele Torre and Giuseppe Russo remain operationally active on the project; their stake is indirect, through Deepleey S.r.l.

The round

Pre-Seed of €500k

To close the IRCCS term sheet, launch the sponsor-funded clinical study and complete the CEO search. Full materials — deck, cap table, use of proceeds — available on request.

€500k
Pre-Seed Round
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Let’s talk

For the full investor deck, the data room, or an introductory call.

Deepleey S.r.l. — Italy

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